However, this does not necessarily mean no interactions exist. Dicyclomine is a muscarinic M1, M3, and M2 receptor antagonist as well as a non-competitive inhibitor of histamine and bradykinin used to treat spasms of the intestines seen in functional bowel disorder and irritable bowel syndrome.3,4,5,6 Though it is commonly prescribed, its recommendation may have been based on a small amount of evidence and so its prescription is becoming less favourable.7, Dicyclomine was granted FDA approval on 11 May 1950.6, Dicyclomine is indicated for the treatment of functional bowel disorder and irritable bowel syndrome.6, Dicyclomine is an anticholinergic drug used to relax the smooth muscles of the intestines.6 It's duration of action is not especially long as it is usually taken 4 times daily with individual doses of 20-40mg orally or 10-20mg by intramuscular injection.6 Dicyclomine should not be administered intravenously.6, Dicyclomine achieves its action partially through direct antimuscarinic activity of the M1, M3, and M2 receptors; and partially through antagonism of bradykinin and histamine.3,4,5,6 Dicyclomine non-competitively inhibits the action of bradykinin and histamine, resulting in direct action on the smooth muscle, and decreased strength of contractions seen in spasms of the ileum.4, The bioavailability of dicyclomine has not been determined,2 though it is likely well absorbed as the primary route of elimination is in the urine.1,6 Dicyclomine has a Tmax of 1-1.5h.6, The volume of distribution for a 20mg oral dose is 3.65L/kg.6, Data regarding plasma protein binding of dicyclomine is not readily available.6, The metabolism of dicyclomine has not been well researched.1, Dicyclomine is 79.5% eliminated in the urine and 8.4% in the feces.1,6, The mean plasma elimination half life is approximately 1.8 hours.1,6, Data regarding the clearance of dicyclomine is not readily available.6, Patients experiencing an overdose may present with headache, nausea, vomiting, blurred vision, dilated pupils, dizziness, dry mouth, difficulty swallowing, CNS stimulation, as well as hot, dry skin.6 Treat patients with gastric lavage, emetics, activated charcoal, sedatives for excitement, and a cholinergic agent if indicated.6. What should I know regarding pregnancy, nursing and administering Dicyclomine HCL to children or the elderly? This isn't an exhaustive list, but here are some common Paxlovid interactions to be aware of. Consult your doctor for more details. 2009 Dec;87(16):3658-70. doi: 10.1002/jnr.22159. Acetylcholine is used by the body to contract smooth (involuntary) muscles in the airways, bladder, blood vessels, gastrointestinal (digestive) tract, and others of the body. But if you need to take ibuprofen for a certain health condition, your healthcare provider may say its OK. Dicyclomine: dicyclomine hydrochloride tablet [drug label]. We and our partners use cookies to Store and/or access information on a device. Uses Dicyclomine is used to treat a certain type of intestinal problem called irritable bowel syndrome. Generic Name: mesalamine This medication is used to treat a certain bowel disease ( ulcerative colitis ). Some are also used for seizures, sleep, and alcohol withdrawal. Dicyclomine should only be used during pregnancy if the benefits outweigh the risks. Other classic symptoms include skin flushing, delirium, and fever. This drug may make you dizzy or drowsy or blur your vision. Ibuprofen causes diuretics to be less effective at removing fluid from the body. A very serious allergic reaction to this drug is rare. If you need to take cyclosporine and ibuprofen, your healthcare provider will likely check your cyclosporine levels more often. Other possible dicyclomine interactions include metoclopramide, glaucoma medications, and antacids. Ibuprofen interacts with methotrexate by causing higher methotrexate levels in the body. RxList does not provide medical advice, diagnosis or treatment. Now, youll enjoy a streamlined experience created specifically for healthcare providers. Do not store in the bathroom. Prescribing, Dosing, Side Effects, and Use During Pregnancy and Nursing. Statins are common medications that lower high cholesterol. Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. Updated 23 Jan 2022 6 answers Dicyclomine - How long does it take for it to take effect? Doing so can reduce the absorption and effectiveness of Bentyl. They work by neutralizing stomach acid. Examples of bisphosphonates include alendronate (Fosamax) and ibandronate (Boniva). He was the founding editor and co-editor in chief of Inflammatory Bowel Diseases. Ans: Dicyclomine is an antispasmodic tablet used for treating specific types of intestinal complication such as irritable bowels syndrome. All rights reserved. doi:10.3238/arztebl.2012.0083. This document does not contain all possible drug interactions. Or they might just ask you to watch closely for anticholinergic side effects. Ask your pharmacist about using those products safely. She was diagnosed with ulcerative colitis at age 16. The symptoms mentioned above may also occur with anticholinergic toxicity. Many other drugs that also cause dry mouth and constipation may interact with anticholinergics/antispasmodics such as dicyclomine. Other blood thinners include antiplatelet medications, like clopidogrel (Plavix) and ticagrelor (Brilinta). Ibuprofen interactions can cause symptoms like bleeding, stomach ulcers, and increased blood pressure. You should avoid taking ibuprofen if youre taking daily low-dose aspirin. Ibuprofen is used to treat the following conditions. You shouldnt take dicyclomine if you have glaucoma. Bentyl has active ingredients of dicyclomine hydrochloride. RemedyRepack Inc. (2022). This information should not be interpreted without the help of a healthcare provider. If the pharmacy that's willing to deliver medicines to your home doesn't have dicyclomine + ibuprofen in stock, you can ask for one of the branded alternatives for dicyclomine + ibuprofen. Amber J. Tresca is a freelance writer and speaker who covers digestive conditions, including IBD. They may also interact with glaucoma medications and antacids. Now, youll enjoy a streamlined experience created specifically for healthcare providers. What conditions does Dicyclomine HCL treat. WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health. You may be able to take ibuprofen for short periods of time if youre taking bisphosphonates. If you are using the liquid form of this medication, carefully measure the dose using a special measuring device/spoon. It also decreases the symptoms of intestinal and stomach cramping. Co-Occuring Bowel Issues in Ankylosing Spondylitis, Bentyl: dicyclomine hydrochloride injection, solution, Dicyclomine: dicyclomine hydrochloride tablet. Dicyclomine isnt commonly used. Talk to your doctor if you are using marijuana (cannabis). GoodRx is not sponsored by or affiliated with any of the third-party brands identified. This could cause you to have higher blood pressure, which can be dangerous. Ibuprofen (Advil, Motrin) is a common medication used for pain and fever. GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. (2020). Bentyl should not be taken at the same time as an antacid, such as Tums, Rolaids, Gaviscon, Maalox, or Mylanta. J Neurosci Res. Below, well discuss four dicyclomine interactions you should know about. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. Get medical help right away if you have any very serious side effects, including: eye pain/swelling/redness, vision changes (such as seeing rainbows around lights at night). Alcohol has many effects on the body. Clinical Drug Interactions Source: Medscape from WebMD. A very serious allergic reaction to this drug is rare. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Wait 30 to 60 minutes before taking any other medications or eating food. If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date. aripiprazole oral. 1. Clinical Drug Interactions Source: Medscape from WebMD. Before taking dicyclomine, ask your healthcare provider and pharmacist to screen for potential interactions. He is the vice chair for ambulatory services for the department of medicine at Weill Cornell Medical College in New York, where he is also a professor. GoodRx works to make its website accessible to all, including those with disabilities. Your condition will not improve any faster and the risk of serious side effects may increase. Store at room temperature away from light and moisture. What You Need to Know About Bentyl (Dicyclomine). Do not use a household spoon because you may not get the correct dose. But some interactions can be serious, and you might need to change medications. This helps relieve the burning sensation you feel with heartburn. 2006 Dec;5(12):993-6. To view the purposes they believe they have legitimate interest for, or to object to this data processing use the vendor list link below. Acetazolamide may increase the excretion rate of Dicyclomine which could result in a lower serum level and potentially a reduction in efficacy. Other drugs that have the same active ingredients (e.g. are known to interact with Enter your email to sign up. Tell your healthcare provider if you have any of the following: Dicyclomine is a pregnancy category B drug, meaning that no harm was reported in animal studies but studies in humans are lacking. 1987 Apr 24;416(1):150-3. doi: 10.1016/0378-4347(87)80496-6. Dosage of drugs is not considered in the study. Dicyclomine [package insert]. Bentyl (dicyclomine) is an antispasmodic drug used to treat intestinal spasms and cramping in people with irritable bowel syndrome (IBS) and other functional bowel disorders. Acyclovir may decrease the excretion rate of Dicyclomine which could result in a higher serum level. This means that taking antacids could make dicyclomine less effective. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. There are also certain drugs that can either lower or increase the concentration of Bentyl in the blood. Before using this medication, tell your doctor or pharmacist your medical history, especially of: personal or family history of glaucoma (angle-closure type), enlarged prostate, problems with urination due to a blocked urinary tract, other stomach/intestinal problems (such as slow gut, blockage, ulcerative colitis, infection, little/no stomach acid, ileostomy/colostomy patients with diarrhea), overactive thyroid, heart problems (such as coronary artery disease, angina, congestive heart failure, fast/irregular heartbeat, heart problems due to severe bleeding), high blood pressure, heartburn problems (such as acid reflux, hiatal hernia, esophagus problems), certain nervous system problem (autonomic neuropathy), personal or family history of a substance use disorder (such as overuse of or addiction to drugs/alcohol), myasthenia gravis, liver problems, kidney problems. Common Magnesium and Ibuprofen interactions: Dizziness: 237 reports Nausea and vomiting: 228 reports Breathing difficulty: 213 reports Fatigue (feeling of tiredness): 206 reports Insomnia (sleeplessness): 164 reports Constipation: 163 reports Depression: 159 reports Browse all drug interactions of Magnesium and Ibuprofen: An example of data being processed may be a unique identifier stored in a cookie. Like many of the interactions covered above, omeprazole can prevent your liver from breaking down diazepam. Dicyclomine belongs to a class of drugs known as anticholinergics/antispasmodics.This medication must not be used by children younger than 6 months old because of the risk of serious side effects. 1997 Feb 12;320(2-3):209-14. This article describes the uses, dosage, risks, side effects, and interactions associated with taking Bentyl. We comply with the HONcode standard for trustworthy health information. Usually avoid combinations; use it only under special circumstances. 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For seizures, sleep, and you might experience with IBS Dicyclomine interactions you should avoid taking ibuprofen if taking... Special circumstances means that taking antacids could make Dicyclomine less effective special measuring device/spoon methotrexate levels in real! The study risks, side effects above, omeprazole can prevent your liver from breaking down diazepam your... Interact with glaucoma medications and antacids any faster and the risk of serious side effects may the... Considered in the body amber J. Tresca is a freelance writer and speaker who covers digestive conditions, IBD! Interactions include metoclopramide, glaucoma medications, like clopidogrel ( Plavix ) and ticagrelor Brilinta... Able to take ibuprofen for short periods of time if youre taking daily low-dose aspirin are to. Bowel Diseases original studies have been referenced on 600+ medical publications including the Lancet, Mayo Proceedings. Email to sign up to Store and/or access information on a device drug is....